- Title
- Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations
- Creator
- Haslam, Danielle E.; Peloso, Gina M.; Guirette, Melanie; Imamura, Fumiaki; Bartz, Traci M.; Pitsillides, Achilleas N.; Wang, Carol A.; Li-Gao, Ruifang; Westra, Jason M.; Pitkanen, Niina; Young, Kristin L.; Graff, Mariaelisa; Wood, Alexis C.; Braun, Kim V. E.; Luan, Jian'an; Kahonen, Mika; Kiefte-de Jong, Jessica C.; Ghanbari, Mohsen; Tintle, Nathan; Lemaitre, Rozenn N.; Mook-Kanamori, Dennis O.; North, Kari; Helminen, Mika; Mossavar-Rahmani, Yasmin; Snetselaar, Linda; Martin, Lisa W.; Viikari, Jorma S.; Oddy, Wendy H.; Pennell, Craig E.; Rosendall, Frits R.; Ikram, M. Arfan; Uitterlinden, Andre G.; Psaty, Bruce M.; Mozaffarian, Dariush; Rotter, Jerome; Taylor, Kent D.; Lehtimaki, Terho; Raitakari, Olli T.; Livingston, Kara A.; Voortman, Trudy; Forouhi, Nita G.; Wareham, Nick J.; de Mutsert, Renee; Rich, Steven S.; Manson, JoAnn E.; Mora, Samia; Ridker, Paul M.; Merino, Jordi; Meigs, James B.; Dashti, Hassan S.; Chasman, Daniel; Lichtenstein, Alice H.; Smith, Caren E.; Dupuis, Josee; Herman, Mark A.; McKeown, Nicola M.
- Relation
- National Institutes of Health (NIH).5T32HL069772-15
- Relation
- Circulation. Genomic and Precision Medicine Vol. 14, Issue 4, p. 506-516
- Publisher Link
- http://dx.doi.org/10.1161/CIRCGEN.120.003288
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2021
- Description
- Background: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia. Methods: Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near CHREBP were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake. Results: In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16–3.07] mg/dL per allele; P<0.0001), but not significantly among the lowest SSB consumers (P=0.81; PDiff <0.0001). Similar results were observed for 2 additional variants (rs35709627 and rs71556736). For triglyceride, rs55673514 was positively associated with triglyceride concentrations only among the highest SSB consumers (β, 0.06 [95% CI, 0.02–0.09] ln-mg/dL per allele, P=0.001) but not the lowest SSB consumers (P=0.84; PDiff=0.0005). Conclusions: Our results identified genetic variants in the CHREBP locus that may protect against SSB-associated reductions in HDL-C and other variants that may exacerbate SSB-associated increases in triglyceride concentrations.
- Subject
- carbohydrates; dyslipidemia; epidemiology; genetics; nutrition; sugars; triglyceride
- Identifier
- http://hdl.handle.net/1959.13/1435557
- Identifier
- uon:39755
- Identifier
- ISSN:2574-8300
- Language
- eng
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